Protein name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1 ;
Alternative:
Phospholipase C-zeta-1 (PLC-zeta-1) ;Phosphoinositide phospholipase C-zeta-1 ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Interacts (via its C2 domain) with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro.
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
Subcellular Location:
Nucleus
Cytoplasm
perinuclear region
Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis.
Protein Attributes:
50:
MENKWFLLMV | RDDFKGGKIT | LEKALKLLEK | LDIQCNTIHV | KYIFKDNDRL |
100:
KQGRITIEEF | RTIYRIITYR | EEIIEIFNTY | SENRKILLEK | NLVEFLMREQ |
150:
YTLDFNKSIA | SEIIQKYEPI | EEVKQAHQMS | FEGFRRYMDS | SECLLFDNKC |
200:
DHVYQDMTHP | LTDYFISSSH | NTYLISDQLW | GPSDLWGYIS | ALVKGCRCLE |
250:
IDCWDGSQNE | PVVYHGYTFT | SKLLFKTVIQ | AINKYAFLAS | EYPVVLSLEN |
300:
HCSPSQQEVM | ADSLLATFGD | ALLSYTLDNF | SDRLPSPEAL | KFKILVRNKK |
350:
IGTLHETLER | KGSDMHGKVE | EFEEEEEIEQ | EEDGSGAKEP | EPVGDFQDDL |
400:
AKEEQLKRVV | GIPLFRKKKI | KISMALSDLV | IYTKVEKFKS | FHHSHLYQQF |
450:
NESNSIGESQ | ARKLTKLAAR | EFILHTRRFI | TRVYPKALRA | DSSNFNPQEF |
500:
WNVGCQMVAL | NFQTPGVPMD | LQNGKFLDNG | CSGYVLKPRF | LRDKKTKFNP |
550:
HKVQIDSNPL | TLTIRLISGI | QLPPSYQNKA | DTLVIVEIFG | VPNDQMKQQS |
600:
RVIKKNAFNP | RWNETFTFVI | QVPELALIRF | VAENQGLIAG | NEFLGQYTLP |
634:
VLCMNRGYRR | VPLFSKMGES | LEPASLFIYV | WYIR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
Rat
Bovine
ELISA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Crossbred X Angus .
tissue :
Liver .
3.
"Fertilization and inositol 1,4,5-trisphosphate (IP3)-induced calcium release in type-1 inositol 1,4,5-trisphosphate receptor down-regulated bovine eggs."
Malcuit C.
,
Knott J.G.
,
He C.
,
Wainwright T.
,
Parys J.B.
,
Robl J.M.
,
Fissore R.A.
Biol. Reprod.73:2-13(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION